A paper from the González’s lab studies how to modify the innate immune response to improve the adaptive immunity against a potential HIV vaccine.
To study this mechanism, we have employed the revolutionary intravital 2-photon imaging available at the IRB in Bellinzona. Using this technique, we have studied the role of a subtype of immune cells called neutrophils alpha and beta in the development of a proper immune response against a HIV vaccine candidate.
This work, directed by Dr. González, represents a collaborative effort between the Infection and Immunity group at the IRB, and the virology group directed from Prof. Mariano Esteban at the CNB in Madrid.
llustration: Recruitment of alpha and beta neutrophils in the spleen after HIV vaccination
Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection
Di Pilato M. , Palomino-Segura M. , Mejías-Pérez E. , Gómez C. E. , Rubio-Ponce A., D’Antuono R. , Pizzagalli D. U. , Pérez P. , Kfuri-Rubens R., Benguría A. , Dopazo A., Ballesteros I., Sorzano C. O. S., Hidalgo A., Esteban M. , Gonzàlez S.
NPJ Vaccines, 2021, 6:52